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Fish Pharmacokinetics Database Updated 31 Aug 2007 | 04:00 pm
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Basics of US Patents and the Patent System 24 Aug 2007 | 04:00 pm
The patent system plays an important role in stimulating the economy and advancing the quality of life in the United States. It serves as an incentive for innovation by giving inventors an exclusive r...
Intellectual Property Policy in the Pharmaceutical Sciences: The Effect of Inappropriate Patents and Market Exclusivity Extensions on the Health Care ... 3 Aug 2007 | 04:00 pm
Though patents are effective tools for promoting innovation and protecting intellectual property in the pharmaceutical sciences, there has been growing concern about 2 important ways that patents in t...
The Influence of Market Exclusivity on Drug Availability and Medical Innovations 3 Aug 2007 | 04:00 pm
The interpretation and application of intellectual property laws is enormously complex in the pharmaceutical industry, with companies needing to obtain multiple patents to fully protect their innovati...
Inactivation of Hepatic Enzymes by Inhalant Nitrite—In Vivo and In Vitro Studies 27 Jul 2007 | 04:00 pm
We examined the effects of acute isobutyl nitrite (ISBN) exposure on the activity of several hepatic enzymes. Two strains of adult male mice (Balb/c and C57BL/6) were exposed to 900 ppm ISBN or ambien...
Biomarkers, Metabonomics, and Drug Development: Can Inborn Errors of Metabolism Help in Understanding Drug Toxicity? 20 Jul 2007 | 04:00 pm
Application of “omics” technology during drug discovery and development is rapidly evolving. This review evaluates the current status and future role of “metabonomics” as a tool in the drug developmen...
Biodegradable Intraprostatic Doxorubicin Implants 29 Jun 2007 | 04:00 pm
Systemic chemotherapy is not effective in the treatment of prostate-confined cancer. We developed biodegradable, doxorubicin-loaded cylinders for intraprostatic implantation and evaluated the feasibil...
O-Phospho-L-Serine, Multi-functional Excipient for B Domain Deleted Recombinant Factor VIII 29 Jun 2007 | 04:00 pm
Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade. A deficiency or dysfunction of FVIII causes hemophilia A, a life-threatening bleeding disorder. FVIII circulates in plasm...
Appropriate Calibration Curve Fitting in Ligand Binding Assays 29 Jun 2007 | 04:00 pm
Calibration curves for ligand binding assays are generally characterized by a nonlinear relationship between the mean response and the analyte concentration. Typically, the response exhibits a sigmoid...
Advanced Pharmacokinetic Models Based on Organ Clearance, Circulatory, and Fractal Concepts 29 Jun 2007 | 04:00 pm
Three advanced models of pharmacokinetics are described. In the first class are physiologically based pharmacokinetic models based on in vitro data on transport and metabolism. The information is tran...
