Physical Presence of Nor-Binaltorphimine in Mouse Brain over 21 Days after a Single Administration Corresponds to Its Long-Lasting Antagonistic Effect... 15 Aug 2013 | 05:32 pm

In the mouse 55°C warm-water tail-withdrawal assay, a single administration of nor-binaltorphimine (nor-BNI; 10 mg/kg i.p.) antagonized -opioid receptor (KOR) agonist-induced antinociception up to 14 ...

Drug-Drug Interactions of the Synthetic Cannabinoids JWH-018 and JWH-073 [HIGHLIGHTED PAPERS] 15 Aug 2013 | 05:32 pm

A Compound Selective for I1-Imidazoline Receptors Improves Metabolic Syndrome [HIGHLIGHTED PAPERS] 15 Aug 2013 | 05:32 pm

JNJ-26854165 Induces Cell Death through Inhibition of Cholesterol Transport [HIGHLIGHTED PAPERS] 15 Aug 2013 | 05:32 pm

Pharmacokinetics and Pharmacodynamics of the GCP II Inhibitor 2-MPPA [HIGHLIGHTED PAPERS] 15 Aug 2013 | 05:32 pm

Pharmacology at Work for Cardio-Oncology: Ranolazine to Treat Early Cardiotoxicity Induced by Antitumor Drugs [Perspectives in Pharmacology] 15 Aug 2013 | 05:32 pm

Antitumor drugs may cause asymptomatic diastolic dysfunction that introduces a lifetime risk of heart failure or myocardial infarction. Cardio-oncology is the discipline committed to the cardiac surve...

Differential Drug-Drug Interactions of the Synthetic Cannabinoids JWH-018 and JWH-073: Implications for Drug Abuse Liability and Pain Therapy [Behavio... 15 Aug 2013 | 05:32 pm

Marijuana substitutes often contain blends of multiple psychoactive synthetic cannabinoids (SCBs), including the prevalent SCBs (1-pentyl-1H-indole-3-yl)-1-naphthalenyl-methanone (JWH-018) and (1-buty...

Fetal Rat Hearts Do Not Display Acute Cardiotoxicity in Response to Maternal Doxorubicin Treatment [Cardiovascular] 15 Aug 2013 | 05:32 pm

Anthracyclines are used to treat cancers during the second and third trimester of pregnancy. The chemotherapeutic effect of anthracyclines is associated with a dose- and time-dependent cardiotoxicity ...

A New Pyrroline Compound Selective for I1-Imidazoline Receptors Improves Metabolic Syndrome in Rats [Cardiovascular] 15 Aug 2013 | 05:32 pm

Symptoms of the metabolic syndrome (MetS), such as insulin resistance, obesity, and hypertension, have been associated with sympathetic hyperactivity. In addition, the adiponectin pathway has interest...

The Novel Anticancer Agent JNJ-26854165 Induces Cell Death through Inhibition of Cholesterol Transport and Degradation of ABCA1 [Chemotherapy, Antibio... 15 Aug 2013 | 05:32 pm

JNJ-26854165 (serdemetan) has previously been reported to inhibit the function of the E3 ligase human double minute 2, and we initially sought to characterize its activity in models of mantle cell lym...