Editorial: Molecular Endocrinology Special Feature Minireviews for August 2013: GPCRs in Endocrine Physiology and Pathophysiology 26 Jul 2013 | 10:00 pm

Minireview: The Effects of Species Ortholog and SNP Variation on Receptors for Free Fatty Acids 26 Jul 2013 | 10:00 pm

Although it is widely assumed that species orthologs of hormone-responsive G protein-coupled receptors will be activated by the same endogenously produced ligand(s), variation in potency, particularly...

Minireview: Nutrient Sensing by G Protein-Coupled Receptors 26 Jul 2013 | 10:00 pm

G protein-coupled receptors (GPCRs) are membrane proteins that recognize molecules in the extracellular milieu and transmit signals inside cells to regulate their behaviors. Ligands for many GPCRs are...

Minireview: Dopaminergic Regulation of Insulin Secretion from the Pancreatic Islet 26 Jul 2013 | 10:00 pm

Exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of dopaminergic neurons in pancreatic islets has led to controversy regarding the importance of this effect. Recent ...

Minireview: Novel Aspects of M3 Muscarinic Receptor Signaling in Pancreatic {beta}-Cells 26 Jul 2013 | 10:00 pm

The release of insulin from pancreatic β-cells is regulated by a considerable number of G protein–coupled receptors. During the past several years, we have focused on the physiological importance of β...

Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 D... 26 Jul 2013 | 10:00 pm

The existence of interindividual variations in G protein-coupled receptor sequences has been recognized early on. Recent advances in large-scale exon sequencing techniques are expected to dramatically...

Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery 26 Jul 2013 | 10:00 pm

The glucagon-like peptide-1 receptor (GLP-1R) controls the physiological responses to the incretin hormone glucagon-like peptide-1 and is a major therapeutic target for the treatment of type 2 diabete...

Novel, Gel-free Proteomics Approach Identifies RNF5 and JAMP as Modulators of GPCR Stability 26 Jul 2013 | 10:00 pm

The maturation and folding of G protein-coupled receptors are governed by mechanisms that remain poorly understood. In an effort to characterize these biological events, we optimized a novel, gel-free...

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag 26 Jul 2013 | 10:00 pm

GPR119 is a G protein-coupled receptor expressed on enteroendocrine L-cells that synthesize and secrete the incretin hormone glucagon-like peptide-1 (GLP-1). Although GPR119 agonists stimulate L-cell ...

Kisspeptin Regulates Gonadotropin Genes via Immediate Early Gene Induction in Pituitary Gonadotropes 26 Jul 2013 | 10:00 pm

Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions including puberty, sex steroid feedback, and overall fertility. Although the importance of Kiss1R in the b...