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Early B Cells as Putative Origin of Merkel Cell Carcinomas 14 Aug 2013 | 09:06 am
Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine nonmelanoma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV). Recently, expression of the terminal deoxynucl...
PCF Meeting Report 14 Aug 2013 | 09:06 am
Prostate Cancer Foundation (PCF) convened its 19th Annual Scientific Retreat October 25–27, 2012, in Carlsbad, CA. Each year, this event brings together diverse researchers in a collaborative forum to...
Metabolic Modifications of HCC Based on Tissue Metabolomics 14 Aug 2013 | 09:06 am
Hepatocellular carcinoma has a poor prognosis due to its rapid development and early metastasis. In this report, we characterized the metabolic features of hepatocellular carcinoma using a nontargeted...
Tumor Targeting of MDSC with Oncolytic Viruses 14 Aug 2013 | 09:06 am
One of the several impediments to effective oncolytic virus therapy of cancer remains a lack of tumor-specific targeting. Myeloid-derived suppressor cells (MDSC) are immature myeloid cells induced by ...
Stromal-Epithelial Interaction in Ovarian Cancer 14 Aug 2013 | 09:06 am
TGF-β has limited effects on ovarian cancer cells, but its contributions to ovarian tumor growth might be mediated through elements of the tumor microenvironment. In the present study, we tested the h...
Molecular Profiling of Canine B-Cell Lymphoma 14 Aug 2013 | 09:06 am
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal mod...
DDB2 Controls Breast Tumor Invasion via NF-{kappa}B 14 Aug 2013 | 09:06 am
The DNA repair protein damaged DNA-binding 2 (DDB2) has been implicated in promoting cell-cycle progression by regulating gene expression. DDB2 is selectively overexpressed in breast tumor cells that ...
EGFR-MET Signaling in NSCLC Metastasis 14 Aug 2013 | 09:06 am
MET amplification as a mechanism of acquired resistance to EGF receptor (EGFR)-targeted therapies in non–small cell lung carcinoma (NSCLC) led to investigation of novel combinations of EGFR and MET ki...
Regulation of Nuclear FHL2 in Cancer by Filamin Cleavage 14 Aug 2013 | 09:06 am
It is now clear that progression from localized prostate cancer to incurable castrate-resistant prostate cancer (CRPC) is driven by continued androgen receptor (AR), signaling independently of androge...
Extracellular RNA and Tumor Growth 14 Aug 2013 | 09:06 am
Extracellular RNA (eRNA) released from injured cells promotes tissue permeability, thrombosis, and inflammation in vitro and in vivo, and RNase1 pretreatment can reduce all these effects. In this stud...
