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Clinical associations of serum interleukin-17 in systemic lupus erythematosus 23 Aug 2013 | 05:00 am
IntroductionSerum interleukin (IL)-17 concentrations have been reported to be increased in systemic lupus erythematosus (SLE), but associations with clinical characteristics are not well understood. W...
Transcriptomic signatures in cartilage ageing 23 Aug 2013 | 05:00 am
IntroductionAge is an important factor in the development of osteoarthritis. Microarray studies provide insight into cartilage ageing but do not reveal the full transcriptomic phenotype of chondrocyte...
Daily physical activity in ankylosing spondylitis: validity and reliability of the IPAQ and SQUASH and the relation with clinical assessments 23 Aug 2013 | 05:00 am
IntroductionThe aim of this study was to investigate the construct validity and test-retest reliability of the International Physical Activity Questionnaire (IPAQ; long form) and the Short QUestionnai...
Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor ... 22 Aug 2013 | 05:00 am
IntroductionIntervertebral disc (IVD) degeneration is characterized by extracellular matrix breakdown and is considered to be a primary cause of discogenic back pain. Although increases in proinflamma...
Association of HLA-DRB1 and -DQB1alleles and haplotypes with rheumatoid arthritis in a Pakistani population 22 Aug 2013 | 05:00 am
IntroductionRheumatoid arthritis is an autoimmune disease with poorly understood pathophysiology. Genetic components of disease etiology, especially HLA associations, are well known. Ethnic difference...
Rheumatoid arthritis is associated with reduced adiposity but not with unfavorable major cardiovascular risk factor profiles and enhanced carotid athe... 22 Aug 2013 | 05:00 am
IntroductionRheumatoid arthritis (RA) is characterized by inflamed joint derived cytokine mediated high-grade systemic inflammation that enhances cardiovascular metabolic risk and disease in developed...
SCORE and REGICOR function charts underestimate the cardiovascular risk in Spanish patients with rheumatoid arthritis 21 Aug 2013 | 05:00 am
IntroductionOur objective was to determine which one of the two function charts available in Spain to calculate the cardiovascular (CV) risk, SCORE or REGICOR, should be used in patients with rheumato...
Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes 21 Aug 2013 | 05:00 am
IntroductionHypoxia is considered to be a positive influence on the healthy chondrocyte phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have been implicated in the ...
Small molecule inhibitors of WNT/beta-catenin signaling block IL1beta/TNFalpha induced cartilage degradation 21 Aug 2013 | 05:00 am
Introduction In this study, we tested the ability of small molecule inhibitors of WNT/beta-catenin signaling to block IL1beta/TNFalpha induced cartilage degradation. Pro-inflammatory cytokines like IL...
Update on differences between childhood-onset and adult-onset systemic lupus erythematosus 21 Aug 2013 | 05:00 am
Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 2...
