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Novel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation [Resource/Methodology] 20 Aug 2013 | 08:15 pm
Monitoring protein synthesis is essential to our understanding of gene expression regulation, as protein abundance is thought to be predominantly controlled at the level of translation. Mass-spectrome...
E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells [Research Papers] 20 Aug 2013 | 08:15 pm
Programmed mutagenesis of the immunoglobulin locus of B lymphocytes during class switch recombination (CSR) and somatic hypermutation requires RNA polymerase II (polII) transcription complex-dependent...
A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication [Research ... 20 Aug 2013 | 08:15 pm
The capacity of polyadenylate-binding protein PABPC1 (PABP1) to stimulate translation is regulated by its repressor, Paip2. Paradoxically, while PABP accumulation promotes human cytomegalovirus (HCMV)...
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence [Research... 20 Aug 2013 | 08:15 pm
Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin i...
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape [Research Papers] 20 Aug 2013 | 08:15 pm
Senescence is a stable proliferation arrest, associated with an altered secretory pathway, thought to promote tumor suppression and tissue aging. While chromatin regulation and lamin B1 down-regulatio...
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence [Research Papers] 20 Aug 2013 | 08:15 pm
The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling pathways that promote NSC quiescence have been identified, the tra...
The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response [Research Papers] 20 Aug 2013 | 08:15 pm
Poly-ADP-ribosylation is a unique post-translational modification participating in many biological processes, such as DNA damage response. Here, we demonstrate that a set of Forkhead-associated (FHA) ...
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry [Research Papers] 20 Aug 2013 | 08:15 pm
The interdependence of p53 and MDM2 is critical for proper cell survival and cell death and, when altered, can lead to tumorigenesis. Mitogen-activated protein kinase (MAPK) signaling pathways functio...
Chromatin targeting drugs in cancer and immunity [Reviews] 20 Aug 2013 | 08:15 pm
Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized ...
How mammals pack their sperm: a variant matter [Perspectives] 3 Aug 2013 | 01:20 am
Producing competent gametes is essential for transmitting genetic information throughout generations. Spermatogenesis is a unique example of rearrangements of genome packaging to ensure fertilization....
