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Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases 29 Jul 2013 | 08:05 pm
Obesity is associated with aberrant sodium/potassium-ATPase (Na+/K+-ATPase) activity, apparently linked to hyperglycemic hyperinsulinemia, which may repress or inactivate the enzyme. The reduction of ...
Hypercapnia counteracts captopril-induced depression of gastric mucosal oxygenation 29 Jul 2013 | 08:05 pm
Hypercapnia (HC) increases systemic oxygen delivery (DO2) and gastric mucosal oxygenation. However, it activates the renin–angiotensin–aldosterone system (RAAS), which conversely reduces mesenteric pe...
Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats 29 Jul 2013 | 08:05 pm
For centuries, Berberine has been used in the treatment of enteritis in China, and it is also known to have anti-hyperglycemic effects in type 2 diabetic patients. However, as Berberine is insoluble a...
Differential effects of GH and GH-releasing peptide-6 on astrocytes 29 Jul 2013 | 08:05 pm
GH and GH secretagogues (GHSs) are involved in many cellular activities such as stimulation of mitosis, proliferation and differentiation. As astrocytes are involved in developmental and protective fu...
Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function 29 Jul 2013 | 08:05 pm
Medical therapy for Cushing's disease (CD) is currently based on agents mainly targeting adrenocortical function. Lately, pituitary-directed drugs have been developed, with limited efficacy. Mitotane,...
Duress without stress: Cryptobia infection results in HPI axis dysfunction in rainbow trout 29 Jul 2013 | 08:05 pm
Despite clear physiological duress, rainbow trout (Oncorhynchus mykiss) infected with the pathogenic haemoflagellate Cryptobia salmositica do not appear to mount a cortisol stress response. Therefore,...
Prostaglandin F2{alpha} upregulates Slit/Robo expression in mouse corpus luteum during luteolysis 29 Jul 2013 | 08:05 pm
Prostaglandin F2α (PGF2α) is a key factor in the triggering of the regression of the corpus luteum (CL). Furthermore, it has been reported that Slit/Robo signaling is involved in the regulation of lut...
Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain 13 Jul 2013 | 10:09 pm
Pathological changes associated with obesity are thought to contribute to GH deficiency. However, recent observations suggest that impaired GH secretion relative to excess calorie consumption contribu...
Evidence for an interaction between proinsulin C-peptide and GPR146 11 Jul 2013 | 07:37 pm
Microvascular diseases, such as retinopathies, neuropathies, and nephropathies, are a devastating consequence of type 1 and type 2 diabetes. The etiology of diabetes-associated microvascular dysfuncti...
Male pubertal development: are endocrine-disrupting compounds shifting the norms? 11 Jul 2013 | 07:37 pm
Endocrine-disrupting compounds (EDCs) are synthetic or natural compounds that interfere with endogenous endocrine action. The frequent use of chemicals with endocrine active properties in household pr...
