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Pathogen-Associated Molecular Patterns Initiate Inflammation and Perturb the Endocrine Function of Bovine Granulosa Cells From Ovarian Dominant Follic... 23 Aug 2013 | 10:01 pm
Bacterial infections of the uterus or mammary gland commonly cause disease and infertility by perturbing growth and steroidogenesis of the dominant follicle in the ovary of cattle. Cells of the innate...
Fibroblast Growth Factor 21 Improves Insulin Resistance and Ameliorates Renal Injury in db/db Mice 23 Aug 2013 | 10:01 pm
Despite the emerging importance of fibroblast growth factor 21 (FGF21) as a metabolic hormone regulating energy balance, its direct effects on renal function remain unexplored. FGF21 was injected ip d...
Full-Length Human Chromogranin-A Cardioactivity: Myocardial, Coronary, and Stimulus-Induced Processing Evidence in Normotensive and Hypertensive Male ... 23 Aug 2013 | 10:01 pm
Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cG...
MiR-133a Modulates Osteogenic Differentiation of Vascular Smooth Muscle Cells 23 Aug 2013 | 10:01 pm
Arterial calcification is a key pathologic component of vascular diseases such as atherosclerosis, coronary artery disease, and peripheral vascular disease. A hallmark of this pathological process is ...
Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas 23 Aug 2013 | 10:01 pm
Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously hypothesized that epithelial mesenchymal transition (EMT) may play a central role in the progressi...
Electrophysiological Differences Between fshb- and lhb-Expressing Gonadotropes in Primary Culture 23 Aug 2013 | 10:01 pm
Synthesis and release of FSH and LH are differentially regulated by GnRH, but the mechanisms by which this regulation is achieved are not well understood. Teleost fish are powerful models for studying...
GHRH Receptor-Targeted Botulinum Neurotoxin Selectively Inhibits Pulsatile GH Secretion in Male Rats 23 Aug 2013 | 10:01 pm
Botulinum neurotoxin is a potent inhibitor of acetylcholine secretion and acts by cleaving members of the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor family, which are critic...
Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats 23 Aug 2013 | 10:01 pm
Gonadal steroids are potent regulators of adult neurogenesis. We previously reported that androgens, such as testosterone (T) and dihydrotestosterone (DHT), but not estradiol, increased the survival o...
Carboxypeptidase E Protects Hippocampal Neurons During Stress in Male Mice by Up-regulating Pro-survival BCL2 Protein Expression 23 Aug 2013 | 10:01 pm
Prolonged chronic stress causing elevated plasma glucocorticoids leads to neurodegeneration. Adaptation to stress (allostasis) through neuroprotective mechanisms can delay this process. Studies on hip...
Developmental GnRH Signaling Is Not Required for Sexual Differentiation of Kisspeptin Neurons but Is Needed for Maximal Kiss1 Gene Expression in Adult... 23 Aug 2013 | 10:01 pm
Kisspeptin, encoded by Kiss1, stimulates reproduction. In rodents, one Kiss1 population resides in the hypothalamic anterior ventral periventricular nucleus and neighboring rostral periventricular nuc...
