ISSUE HIGHLIGHTS [Issue Highlights] 1 Aug 2013 | 05:40 pm

We Have Met the Enemy, and It Is Us [Editorial] 1 Aug 2013 | 05:40 pm

Lamarck, Evolution, and the Inheritance of Acquired Characters [Perspectives] 1 Aug 2013 | 05:40 pm

Scientists are not always remembered for the ideas they cherished most. In the case of the French biologist Jean-Baptiste Lamarck, his name since the end of the nineteenth century has been tightly lin...

The Molecular Genetics of Insecticide Resistance [Review] 1 Aug 2013 | 05:40 pm

The past 60 years have seen a revolution in our understanding of the molecular genetics of insecticide resistance. While at first the field was split by arguments about the relative importance of mono...

The Composition, Functions, and Regulation of the Budding Yeast Kinetochore [Genome Organization and Integrity] 1 Aug 2013 | 05:40 pm

The propagation of all organisms depends on the accurate and orderly segregation of chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding model organism to identify the c...

The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence [Genome Integrity and Transmission] 1 Aug 2013 | 05:40 pm

The absence of telomerase in many eukaryotes leads to the gradual shortening of telomeres, causing replicative senescence. In humans, this proliferation barrier constitutes a tumor suppressor mechanis...

Remodeling of the Rad51 DNA Strand-Exchange Protein by the Srs2 Helicase [Genome Integrity and Transmission] 1 Aug 2013 | 05:40 pm

Homologous recombination is associated with the dynamic assembly and disassembly of DNA–protein complexes. Assembly of a nucleoprotein filament comprising ssDNA and the RecA homolog, Rad51, is a key s...

Functional Characterization of Fission Yeast Transcription Factors by Overexpression Analysis [Gene Expression] 1 Aug 2013 | 05:40 pm

In Schizosaccharomyces pombe, over 90% of transcription factor genes are nonessential. Moreover, the majority do not exhibit significant growth defects under optimal conditions when deleted, complicat...

Defining Specificity Determinants of cGMP Mediated Gustatory Sensory Transduction in Caenorhabditis elegans [Developmental and Behavioral Genetics] 1 Aug 2013 | 05:40 pm

Cyclic guanosine monophosphate (cGMP) is a key secondary messenger used in signal transduction in various types of sensory neurons. The importance of cGMP in the ASE gustatory receptor neurons of the ...

Probing the Boundaries of Orthology: The Unanticipated Rapid Evolution of Drosophila centrosomin [Developmental and Behavioral Genetics] 1 Aug 2013 | 05:40 pm

The rapid evolution of essential developmental genes and their protein products is both intriguing and problematic. The rapid evolution of gene products with simple protein folds and a lack of well-ch...