Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice 1 Aug 2013 | 09:00 pm

Chronic inflammation in arterial wall that is driven by immune cells and cytokines plays pivotal roles in the development of atherosclerosis. Interleukin 27 (IL-27) is a member of the IL-12 family of ...

Civil, sensible, and constructive peer review in APS journals 1 Aug 2013 | 09:00 pm

Regulation of the proteasome by ATP: implications for ischemic myocardial injury and donor heart preservation 1 Aug 2013 | 09:00 pm

Several lines of evidence suggest that proteasomes are involved in multiple aspects of myocardial physiology and pathology, including myocardial ischemia-reperfusion injury. It is well established tha...

Diagnosing vascular variability anomalies, not only MESOR-hypertension 1 Aug 2013 | 09:00 pm

Chronobiology is the study of biological rhythms. Chronomics investigates interactions with environmental cycles in a genetically coded autoresonance of the biosphere with wrangling space and terrestr...

Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes 1 Aug 2013 | 09:00 pm

Glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) is a remedy for type 2 diabetes mellitus (T2DM). Ex-4 ameliorates cardiac dysfunction induced by myocardial infarction in preclinical...

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through {beta}1-integrin and VEGFR2 1 Aug 2013 | 09:00 pm

How single-chain urokinase (ScuPA) mediates angiogenesis is incompletely understood. ScuPA (≥4 nM) induces phosphorylated (p)ERK1/2 (MAPK44 and MAPK42) and pAkt (Ser473) in umbilical vein and dermal m...

Pressure-induced maturation of endothelial cells on newborn mouse carotid arteries 1 Aug 2013 | 09:00 pm

Experiments investigated maturation of endothelial function in the postnatal period. Carotid arteries isolated from newborn (postnatal day 1, P1) to P21 mice were assessed in myographs at transmural p...

Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1{alpha} 1 Aug 2013 | 09:00 pm

The activity of glucose-6-phosphate dehydrogenase (G6PD) appears to control a vascular smooth muscle relaxing mechanism regulated through cytosolic NADPH oxidation. Since our recent studies suggest th...

Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat 1 Aug 2013 | 09:00 pm

A contributing factor to increased peripheral resistance seen during hypertension is an increased production of endothelium-derived contractile factors (EDCFs). The main EDCFs are vasoconstrictor pros...

Distinct loading conditions reveal various patterns of right ventricular adaptation 1 Aug 2013 | 09:00 pm

Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types of RV loading h...