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Can hypercalcemia be caused by hydrochlorothiazide itself or must there be an underlying calcium issue? 27 Aug 2013 | 04:52 pm
In this study hypercalcemia was identified a mean of 6 ± 7 years after thiazide initiation, and the average highest serum calcium was 10.7 ± 0.3 mg/dL with serum parathyroid hormone (obtained in 53 pa...
In patients with respiratory illness, how useful are the chest exam findings in the diagnosis of community-acquired pneumonia? 22 Aug 2013 | 10:32 pm
Bottom line: Although some chest exam findings are more suggestive of pneumonia than others, none is sufficient to rule out a diagnosis of pneumonia. If pneumonia is on the differential, then the pa...
How do fomepizole and ethanol compare for treating ethylene glycol poisoning? 15 Aug 2013 | 12:14 am
Bottom line: There are no direct comparisons of fomepizole and ethanol in teating ethylene glycol poisoning. American Academy of Clinical Toxicology recommends fomepizole over ethanol in cases invol...
Review of febrile rash 14 Aug 2013 | 10:52 pm
Differential diagnosis for febrile patients with a rash is extensive. Diseases that present with fever and rash are usually classified according to the morphology of the primary lesion. Rashes can be ...
What is the approach to a patient with fever recent travel history? 14 Aug 2013 | 10:51 pm
Fever is an important and relatively common presentation of infections in returning travellers. The most common infections diagnosed in febrile returning travellers are malaria, dengue, mononucleosis,...
What is the mechanism of oxcarbazepine induced hyponatremia? 6 Aug 2013 | 07:24 pm
Antidiuretic effects of oxcarbazepine, which is structurally related to carbamazepine, have also been observed. Owing to the structural similarity, one would expect that the mechanism by which oxcarba...
Review of hepatorenal syndrome 6 Aug 2013 | 07:19 pm
The Bottom Line: Hepatorenal syndrome is defined as a functional renal failure in patients with liver disease with portal hypertension and it constitutes the climax of systemic circulatory changes ass...
How does the Wells score affect pre-test probability of a venous thromboembolism and how does it figure into management? 31 Jul 2013 | 04:21 pm
ICSI Healthcare guideline venous thromboembolism diagnosis & treatment, 2013. Clinical prediction of pulmonary embolism. In: DynaMed. Modified Wells criteria: +3 Clinical Signs of DVT (leg swelling...
In diagnosing tuberculosis, what is the sensitivity of the Xpert MTB/RIF assay compared to direct TB stain? 31 Jul 2013 | 01:37 am
The Bottom Line: The Xpert MTB/RIF assay has a sensitivity that is roughly two orders of magnitude greater than that of smear microscopy. Reference: Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, ...
Is the ventilation perfusion lung scan still useful in diagnosing pulmonary embolism? 25 Jul 2013 | 10:18 pm
Bottom line: A diagnostic strategy combining clinical assessment, d-dimer, ultrasonography, and lung scan can provide a noninvasive diagnosis before conducting a CT scan can provide a diagnosis in a m...
