Clinicalepigeneticsjournal - clinicalepigeneticsjournal.com - Clinical Epigenetics - Latest Articles
General Information:
Latest News:
The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia 1 Aug 2013 | 05:00 am
Background: A large proportion of patients with acute myeloid leukemia (AML) are not fit for intensive and potentially curative therapy due to advanced age or comorbidity. Previous studies have demons...
Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experi... 30 Jul 2013 | 05:00 am
Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition ...
Transcription factor NFkappaB regulates the expression of the histone deacetylase SIRT1 19 Jul 2013 | 05:00 am
Background: The Nad-dependent protein deacetylase Sirt1 has a wide range of different targets, which may be regulated either directly through deacetylation and thus potentially altering their activity...
Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis 11 Jul 2013 | 05:00 am
Background: Sirtuin 1 (Sirt1) is a nuclear enzyme from the class III histone deacetylases that modulates gene expression and is involved in bone and cartilage remodeling. The goal of our study was to ...
Specific inhibition of one DNMT1-including complex influences tumor initiation and progression 28 Jun 2013 | 05:00 am
Background: Reactivation of silenced tumor suppressor genes by DNMT inhibitors has provided an alternative approach to cancer therapy. However, DNMT inhibitors have also been shown to induce or enhanc...
Tissue-specific DNA methylation profiles in newborns 31 May 2013 | 05:00 am
Background: Epidemiological studies demonstrate that foetal growth restriction and low birth weight affect long-term health. Derangements in tissue-specific epigenetic programming of foetal and placen...
DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population 2 May 2013 | 05:00 am
Background: DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA met...
Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia 26 Apr 2013 | 05:00 am
Background: Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in unde...
Variation in ultraviolet radiation and diabetes: evidence of an epigenetic effect that modulates diabetics' lifespan 2 Apr 2013 | 05:00 am
Background: Published research has shown that month-of-birth variations modulate the incidence of adult human diseases. This article explores diabetes type 2 as one of those diseases. This study uses ...
Reviewer Acknowledgement 2013 2 Apr 2013 | 05:00 am
Contributing reviewersThe editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 4 (2012).
